Stephen Hawking, who sought to explain some of the most complicated questions of life while himself working under the shadow of a likely premature death, has died at 76.

The UK's Press Association reported his death, citing a spokesman for the family.

Hawking's formidable mind probed the very limits of human understanding both in the vastness of space and in the bizarre sub-molecular world of quantum theory, which he said could predict what happens at the beginning and end of time.

His work ranged from the origins of the universe itself, through the tantalising prospect of time travel to the mysteries of space's all-consuming black holes.

But the power of his intellect contrasted cruelly with the weakness of his body, ravaged by the wasting motor neurone disease he contracted at the age of 21.